General description

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.^1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.³ Wilms’; tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.¹ CITED1 expression has been shown to persist in blastemal cell populations of human WT.^1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.^1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.¹ CITED1 has been detected in 86.8% of WT Cases.²

Legal Information

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Linkage

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality